Cabergoline is rapidly and extensively metabolized in the liver and excreted in bile and to a lesser extent in urine. All metabolites are less active than the parental drug or inactive altogether. The human elimination half-life is estimated to be 63 to 68 hours https://standprincipal.pt/maximizing-muscle-growth-tips-and-strategies-for/ in patients with Parkinson’s disease and 79 to 115 hours in patients with pituitary tumors. Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome.
- This happens when your pituitary gland makes extra prolactin.
- After oral dosing of radioactive cabergoline to five healthy volunteers, approximately 22% and 60% of the dose was excreted within 20 days in the urine and feces, respectively.
- Your doctor will write the number of refills authorized on your prescription.
- Dopamine antagonists such as antipsychotics and metoclopramide counteract some effects of cabergoline.
- You should not need a new prescription for this medication to be refilled.
The extremely long bioavailability of the medication may complicate dosing regimens during titration and require particular precautions. If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room right away.
How to take cabergoline
The drug should not be combined with other ergot derivatives. Dopamine antagonists such as antipsychotics and metoclopramide counteract some effects of cabergoline. The use of antihypertensive drugs should be intensively monitored because excessive hypotension may result from the combination. Cabergoline is a dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes. To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking.
What is cabergoline?
Your doctor will probably start you on a low dose of cabergoline and gradually increase your dose, not more often than once every 4 weeks. After oral dosing of radioactive cabergoline to five healthy volunteers, approximately 22% and 60% of the dose was excreted within 20 days in the urine and feces, respectively. Less than 4% of the dose was excreted unchanged in the urine. Examples of drugs that can cause interactions with cabergoline are listed below. Typical doses of Cabergoline are 0.25mg taken twice per week.
Do not take more or less of it or take it more often than prescribed by your doctor. Cabergoline is also sometimes used to treat Parkinson’s disease (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance). Talk to your doctor about the risks of using this medication for your condition. For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). The kidneys and liver of older adults may not work as well as they used to. As a result, more of a drug stays in your body for a longer time.